2023

Eiseler K, Neppl L, Schmidt AW, Rauscher B, Ewers M, Masson E, Chen JM, Férec C, Rebours V, Grammatikopoulos T, Foskett P, Greenhalf W, Halloran C, Neoptolemos J, Haack TB, Ossowski S, Sturm M, Rosendahl J, Laumen H, Witt H. Genetic and functional analysis of chymotrypsin-like protease (CTRL) in chronic pancreatitis. Pancreatology 2023; 23(8): 957-963. doi: 10.1016/j.pan.2023.11.002. PMID: 37949771. Pubmed

Masson E, Ewers M, Paliwal S, Kume K, Scotet V, Cooper DN, Rebours V, Buscail L, Rouault K; GREPAN (Genetic REsearch on PANcreatitis) Study Group; Abrantes A, Aguilera Munoz L, Albouys J, Alric L, Amiot X, Archambeaud I, Audiau S, Bastide L, Baudon J, Bellaiche G, Bellon S, Bertrand V, Bideau K, Billiemaz K, Billioud C, Bonnefoy S, Borderon C, Bournet B, Breton E, Brugel M, Buscail L, Cadiot G, Camus M, Carpentier-Pourquier M, Chamouard P, Chaput U, Chen JM, Cholet F, Ciocan DM, Clavel C, Coffin B, Coimet-Berger L, Cosconea S, Creveaux I, Culetto A, Daboussi O, De Mestier L, Degand T, D'engremont C, Denis B, Dermine S, Desgrippes, Drouet D'Aubigny A, Enaud R, Fabre A, Férec C, Gargot D, Gelsi E, Gentilcore E, Gincul R, Ginglinger-Favre E, Giovannini M, Gomercic C, Gondran H, Grainville T, Grandval P, Grasset D, Grimaldi S, Grimbert S, Hagege H, Heissat S, Hentic O, Herber-Mayne A, Hervouet M, Hoibian S, Jacques J, Jais B, Kaassis M, Koch S, Lacaze E, Lacroute J, Lamireau T, Laurent L, Le Guillou X, Le Rhun M, Leblanc S, Levy P, Lievre A, Lorenzo D, Maire F, Marcel K, Masson E, Mauillon J, Morgant S, Moussata D, Muller N, Nambot S, Napoleon B, Olivier A, Pagenault M, Pelletier AL, Pennec O, Pinard F, Pioche M, Prost B, Queneherve L, Rebours V, Reboux N, Rekik S, Riachi G, Rohmer B, Roquelaure B, Hezode IR, Rostain F, Saurin JC, Servais L, Stan-Iuga R, Subtil C, Tanneche J, Texier C, Thomassin L, Tougeron D, Vuitton L, Wallenhorst T, Wangerme M, Zanaldi H, Zerbib F, Bhaskar S, Kikuta K, Rao GV, Hamada S, Reddy DN, Masamune A, Chandak GR, Witt H, Férec C, Chen JM. The PRSS3P2 and TRY7 deletion copy number variant modifies risk for chronic pancreatitis. Pancreatology 2023; 23(1): 48-56. doi: 10.1016/j.pan.2022.11.013. PMID: 36517351. Pubmed

Wasnick R, Korfei M, Piskulak K, Henneke I, Wilhelm J, Mahavadi P, Dartsch RC, von der Beck D, Koch M, Shalashova I, Weiss A, Klymenko O, Askevold I, Fink L, Witt H, Hackstein H, El Agha E, Bellusci S, Klepetko W, Königshoff M, Eickelberg O, Schermuly RT, Braun T, Seeger W, Ruppert C, Guenther A. Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis. Am J Respir Crit Care Med. 2023; 207(3): 283-299. doi: 10.1164/rccm.202105-1284OC. PMID: 36047984. Pubmed

2022

Neubauer C, Ewers M, Schulz HU, Weiß FU, Lämmerhirt F, Lerch MM, Bugert P, Landt O, Algül H, Rosendahl J, Witt H. Genetic Analysis of the ATG16L1 c.898A>G (p.T300A) Variant in Acute and Chronic Pancreatitis. Pancreas 2022; 51(9): 1231-1234. doi: 10.1097/MPA.0000000000002177. PMID: 37078950. Pubmed

Eiseler K, Dropmann LM, Bugert P, Ewers M, Witt H. Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis. Pancreatology 2022; 22(8): 1079-1083. doi: 10.1016/j.pan.2022.09.240. PMID: 36167651. Pubmed

Tóth A, Demcsák A, Zankl F, Oracz G, Unger LS, Bugert P, Laumen H, Párniczky A, Hegyi P, Rosendahl J, Gambin T, Płoski R, Koziel D, Gluszek S, Lindgren F, Löhr JM, Sahin-Tóth M, Witt H, Rygiel AM, Ewers M, Hegyi E. Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis. Pancreatology 2022; 22(6): 713-718. doi: 10.1016/j.pan.2022.06.258. PMID: 35773178. Pubmed (pdf-Datei).

Takáts A, Berke G, Gede N, Németh BC, Witt H, Głuszek S, Rygiel AM, Hegyi P, Sahin-Tóth M, Hegyi E. Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants: A meta-analysis. PLoS One. 2022; 17(5): e0268859. doi: 10.1371/journal.pone.0268859. eCollection 2022. PMID: 35594281 Free PMC article. Pubmed

Rygiel AM, Unger LS, Sörgel FL, Masson E, Matsumoto R, Ewers M, Chen JM, Bugert P, Buscail L, Gambin T, Oracz G, Winiewska-Szajewska M, Mianowska A, Poznanski J, Kosińska J, Stawinski P, Płoski R, Koziel D, Gluszek S, Laumen H, Lindgren F, Löhr JM, Orekhova A, Rebours V, Rosendahl J, Párniczky A, Hegyi P, Sasaki A, Kataoka F, Tanaka Y, Hamada S, Sahin-Tóth M, Hegyi E, Férec C, Masamune A, Witt H. Variants in the pancreatic CUB and zona pellucida-like domains 1 (CUZD1) gene in early-onset chronic pancreatitis - A possible new susceptibility gene. Pancreatology 2022; 22(5): 564-571. doi: 10.1016/j.pan.2022.04.015. Epub 2022 May 1. PMID: 35589511. Pubmed (pdf-Datei).

Schmidt AW, Kühnapfel A, Kirsten H, Grallert H, Hellerbrand C, Kiefer F, Mann K, Mueller S, Nöthen MM, Peters A, Ridinger M, Frank J, Rietschel M, Soranzo N, Soyka M, Wodarz N, Malerba G, Gambaro G, Gieger C, Scholz M, Krug S, Michl P, Ewers M, Witt H, Laumen H, Rosendahl J. Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms. Pancreatology 2022; 22(4): 449-456. doi: 10.1016/j.pan.2022.03.007. PMID: 35331647. Pubmed

Ewers M, Epple D, Bugert P, Rosendahl J, Witt H. Genetic analysis of pancreatic phospholipase A2 (PLA2G1B) in patients with chronic pancreatitis. Pancreatology 2022; 22(2): 244-247. doi: 10.1016/j.pan.2022.01.003. PMID: 35031208. Pubmed

2021

Oracz G, Zaród M, Ewers M, Laumen H, Gambin T, Kamiński P, Grabowska I, Drożak A, Kwiatkowski S, Wertheim-Tysarowska K, Kołodziejczyk E, Domaszewicz A, Dorożko B, Kosińska J, Głuszek S, Kozieł D, Płoski R, Rosendahl J, Witt H, Drożak J, Rygiel AM. Loss of function TRPV6 variants are associated with chronic pancreatitis in nonalcoholic early-onset Polish and German patients. Pancreatology 2021; 21(8): 1434-1442. doi: 10.1016/j.pan.2021.09.005. PMID: 34538581. Pubmed

Rosendahl J, Witt H. [Pathogenesis of chronic pancreatitis]. Internist (Berl). 2021; 62(10): 1007-1014. doi: 10.1007/s00108-021-01150-6. PMID: 34524468 Review. German. Pubmed

Ewers M, Canaff L, Weh AE, Masson E, Eiseler K, Chen JM, Rebours V, Bugert P, Michl P, Rosendahl J, Férec C, Goltzman D, Witt H. The three common polymorphisms p.A986S, p.R990G and p.Q1011E in the calcium sensing receptor (CASR) are not associated with chronic pancreatitis. Pancreatology 2021; 21(7): 1299-1304. doi: 10.1016/j.pan.2021.08.008. PMID: 34446336. Pubmed

2020

Masamune A, Kotani H, Sörgel FL, Chen JM, Hamada S, Sakaguchi R, Masson E, Nakano E, Kakuta Y, Niihori T, Funayama R, Shirota M, Hirano T, Kawamoto T, Hosokoshi A, Kume K, Unger L, Ewers M, Laumen H, Bugert P, Mori MX, Tsvilovskyy V, Weißgerber P, Kriebs U, Fecher-Trost C, Freichel M, Diakopoulos KN, Berninger A, Lesina M, Ishii K, Itoi T, Ikeura T, Okazaki K, Kaune T, Rosendahl J, Nagasaki M, Uezono Y, Algül H, Nakayama K, Matsubara Y, Aoki Y, Férec C, Mori Y, Witt H, Shimosegawa T: Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis. Gastroenterology 2020; 158(6): 1626-1641. Pubmed

Seltsam K, Pentner C, Weigl F, Sutedjo S, Zimmer C, Beer S, Bugert P, Ewers M, Ruffert C, Michl P, Laumen H, Witt H, Rosendahl J. Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis. Pancreatology 2020; 20(8): 1598-1603. doi: 10.1016/j.pan.2020.09.017. PMID: 33036922. Pubmed

Kaune T, Ruffert C, Hesselbarth N, Damm M, Krug S, Cardinal von Widdern J, Masson E, Chen JM, Rebours V, Buscail L, Férec C, Grützmann R, Te Morsche RHM, Drenth JP, Cavestro GM, Zuppardo RA, Saftoiu A, Malecka-Panas E, Głuszek S, Bugert P, Lerch MM, Sendler M, Weiss FU, Zou WB, Deng SJ, Liao Z, Scholz M, Kirsten H, Hegyi P, Witt H, Michl P, Griesmann H, Rosendahl J. Analysis of GPRC6A variants in different pancreatitis etiologies. Pancreatology 2020; 20(7): 1262-1267. doi: 10.1016/j.pan.2020.08.001. PMID: 32859544. Pubmed

Löhr JM, Beuers U, Vujasinovic M, Alvaro D, Frøkjær JB, Buttgereit F, Capurso G, Culver EL, de-Madaria E, Della-Torre E, Detlefsen S, Dominguez-Muñoz E, Czubkowski P, Ewald N, Frulloni L, Gubergrits N, Duman DG, Hackert T, Iglesias-Garcia J, Kartalis N, Laghi A, Lammert F, Lindgren F, Okhlobystin A, Oracz G, Parniczky A, Mucelli RMP, Rebours V, Rosendahl J, Schleinitz N, Schneider A, van Bommel EF, Verbeke CS, Vullierme MP, Witt H; UEG guideline working group. European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations. United European Gastroenterol J. 2020; 8(6): 637-666. doi: 10.1177/2050640620934911. PMID: 32552502; PMCID: PMC7437085. Pubmed

De Grandi A, Franzini M, Rosipal Š, Rosipal R, Debreova M, Corti A, Ruetzler-Dichtl E, Scholl-Bürgi S, Paolicchi A, Pompella A, Emdin M, Zampa G, Witt H, Zoller H, Tilg H, Mayatepek E, Herebian D, Pramstaller PP, Müller T, Janecke AR. Highly Elevated Plasma γ-Glutamyltransferase Elevations: A Trait Caused by γ-Glutamyltransferase 1 Transmembrane Mutations. Hepatology 2020; 71(3): 1124-1127. Pubmed

2019

Kaune T, Hollenbach M, Keil B, Chen JM, Masson E, Becker C, Damm M, Ruffert C, Grützmann R, Hoffmeister A, Te Morsche RHM, Cavestro GM, Zuppardo RA, Saftoiu A, Malecka-Panas E, Głuszek S, Bugert P, Lerch MM, Weiss FU, Zou WB, Liao Z, Hegyi P, Drenth JP, Riedel J, Férec C, Scholz M, Kirsten H, Tóth A, Ewers M, Witt H, Griesmann H, Michl P, Rosendahl J. Common variants in glyoxalase I do not increase chronic pancreatitis risk. PLoS One 2019; 14(10):e0222927. doi: 10.1371/journal.pone.0222927. eCollection 2019. Pubmed

Matejka K, Stückler F, Salomon M, Ensenauer R, Reischl E, Hoerburger L, Grallert H, Kastenmüller G, Peters A, Daniel H, Krumsiek J, Theis FJ, Hauner H, Laumen H. Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants. PLoS One. 2019;14(5):e0216110. doi: 10.1371/journal.pone.0216110. eCollection 2019. Pubmed

Lasher D, Szabó A, Masamune A, Chen JM, Xiao X, Whitcomb DC, Barmada MM, Ewers M, Ruffert C, Paliwal S, Issarapu P, Bhaskar S, Mani KR, Chandak GR, Laumen H, Masson E, Kume K, Hamada S, Nakano E, Seltsam K, Bugert P, Müller T, Groneberg DA, Shimosegawa T, Rosendahl J, Férec C, Lowe ME, Witt H, Sahin-Tóth M. Protease-sensitive pancreatic lipase variants are associated with early onset chronic pancreatitis. Am J Gastroenterol. 2019; doi: 10.14309/ajg.0000000000000051. Pubmed

Hedl M, Yan J, Witt H, Abraham C. IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome. J Immunol. 2019;202(3):920-930. doi: 10.4049/jimmunol.1800226. Pubmed

2018

Dominguez-Munoz JE, Drewes AM, Lindkvist B, Ewald N, Czakó L, Rosendahl J, Löhr JM; HaPanEU/UEG Working Group. Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis. Pancreatology. 2018;18(8):847-854. doi: 10.1016/j.pan.2018.09.016. Review. Pubmed

Weiss FU, Hesselbarth N, Párniczky A, Mosztbacher D, Lämmerhirt F, Ruffert C, Kovacs P, Beer S, Seltsam K, Griesmann H, Böhme R, Kaune T, Hollenbach M, Schulz HU, Simon P, Mayerle J, Lerch MM, Cavestro GM, Zuppardo RA, Di Leo M, Testoni PA, Malecka-Panas E, Gasirowska A, Głuszek S, Bugert P, Szentesi A, Mössner J, Witt H, Michl P, Hégyi P, Scholz M, Rosendahl J. Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis.Pancreatology. 2018; 18(5): 477-481. doi: 10.1016/j.pan.2018.05.486. Pubmed

Rosendahl J, Kirsten H, Hegyi E, Kovacs P, Weiss FU, Laumen H, Lichtner P, Ruffert C, Chen JM, Masson E, Beer S, Zimmer C, Seltsam K, Algül H, Bühler F, Bruno MJ, Bugert P, Burkhardt R, Cavestro GM, Cichoz-Lach H, Farré A, Frank J, Gambaro G, Gimpfl S, Grallert H, Griesmann H, Grützmann R, Hellerbrand C, Hegyi P, Hollenbach M, Iordache S, Jurkowska G, Keim V, Kiefer F, Krug S, Landt O, Leo MD, Lerch MM, Lévy P, Löffler M, Löhr M, Ludwig M, Macek M, Malats N, Malecka-Panas E, Malerba G, Mann K, Mayerle J, Mohr S, Te Morsche RHM, Motyka M, Mueller S, Müller T, Nöthen MM, Pedrazzoli S, Pereira SP, Peters A, Pfützer R, Real FX, Rebours V, Ridinger M, Rietschel M, Rösmann E, Saftoiu A, Schneider A, Schulz HU, Soranzo N, Soyka M, Simon P, Skipworth J, Stickel F, Strauch K, Stumvoll M, Testoni PA, Tönjes A, Werner L, Werner J, Wodarz N, Ziegler M, Masamune A, Mössner J, Férec C, Michl P, P H Drenth J, Witt H, Scholz M, Sahin-Tóth M; all members of the PanEuropean Working group on ACP.Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.Gut. 2018;67(10):1855-18637. doi: 10.1136/gutjnl-2017-314454. Pubmed (pdf-Datei).

Párniczky A, Abu-El-Haija M, Husain S, Lowe M, Oracz G, Sahin-Tóth M, Szabó FK, Uc A, Wilschanski M, Witt H, Czakó L, Grammatikopoulos T, Rasmussen IC, Sutton R, Hegyi P.EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis.Pancreatology. 2018;18(2):146-160. doi: 10.1016/j.pan.2018.01.001. Review. Pubmed (pdf-Datei).

Ebert K, Ewers M, Bisha I, Sander S, Rasputniac T, Daniel H, Antes I, Witt H.Identification of essential amino acids for glucose transporter 5 (GLUT5)-mediated fructose transport.J Biol Chem. 2018;293(6):2115-2124. doi: 10.1074/jbc.RA117.001442. Pubmed

2017

Lee H, Qian K, von Toerne C, Hoerburger L, Claussnitzer M, Hoffmann C, Glunk V, Wahl S, Breier M, Eck F, Jafari L, Molnos S, Grallert H, Dahlman I, Arner P, Brunner C, Hauner H, Hauck SM, Laumen H.Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation.Nucleic Acids Res. 2017;45(6):3266-3279. doi: 10.1093/nar/gkx105. Pubmed (pdf-Datei).

Witt H. [No Magic Bullet: Genetic Diagnostics and Predictive Testing].Dtsch Med Wochenschr. 2017;142(9):652-656. doi: 10.1055/s-0043-101829. German. Pubmed

Löhr JM, Dominguez-Munoz E, Rosendahl J, Besselink M, Mayerle J, Lerch MM, Haas S, Akisik F, Kartalis N, Iglesias-Garcia J, Keller J, Boermeester M, Werner J, Dumonceau JM, Fockens P, Drewes A, Ceyhan G, Lindkvist B, Drenth J, Ewald N, Hardt P, de Madaria E, Witt H, Schneider A, Manfredi R, Brøndum FJ, Rudolf S, Bollen T, Bruno M; HaPanEU/UEG Working Group.United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU).United European Gastroenterol J. 2017;5(2):153-199. doi: 10.1177/2050640616684695. Review. Pubmed (pdf-Datei).

Ebert K, Ludwig M, Geillinger KE, Schoberth GC, Essenwanger J, Stolz J, Daniel H, Witt H.Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters.J Membr Biol. 2017;250(2):171-182. doi: 10.1007/s00232-016-9945-7. Pubmed

2016

Ebert K, Witt H.Fructose malabsorption.Mol Cell Pediatr. 2016;3(1):10. doi: 10.1186/s40348-016-0035-9. Pubmed (pdf-Datei).

Mueller T, Fischer J, Gessner R, Rosendahl J, Böhm S, van Bömmel F, Knop V, Sarrazin C, Witt H, Marques AM, Kovacs P, Schleinitz D, Stumvoll M, Blüher M, Bugert P, Schott E, Berg T.Apolipoprotein E allele frequencies in chronic and self-limited hepatitis C suggest a protective effect of APOE4 in the course of hepatitis C virus infection.Liver Int. 2016;36(9):1267-74. doi: 10.1111/liv.13094. Pubmed

Szabó A, Pilsak C, Bence M, Witt H, Sahin-Tóth M.Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.J Biol Chem. 2016;291(34):17706-16. doi: 10.1074/jbc.M116.743237. Pubmed (pdf-Datei).

Müller T, Rasool I, Heinz-Erian P, Mildenberger E, Hülstrunk C, Müller A, Michaud L, Koot BG, Ballauff A, Vodopiutz J, Rosipal S, Petersen BS, Franke A, Fuchs I, Witt H, Zoller H, Janecke AR, Visweswariah SS.Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C.Gut. 2016;65(8):1306-13. doi: 10.1136/gutjnl-2015-309441. Pubmed (pdf-Datei).

Nestor CE, Lentini A, Hägg Nilsson C, Gawel DR, Gustafsson M, Mattson L, Wang H, Rundquist O, Meehan RR, Klocke B, Seifert M, Hauck SM, Laumen H, Zhang H, Benson M. 5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells. Cell Rep. 2016;16(2):559-570. doi: 10.1016/j.celrep.2016.05.091. Pubmed (pdf-Datei).

Strawbridge RJ, Laumen H, Hamsten A, Breier M, Grallert H, Hauner H, Arner P, Dahlman I.Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis.PLoS One. 2016;11(4):e0153990. doi: 10.1371/journal.pone.0153990. eCollection 2016. Pubmed (pdf-Datei).

Song L, Wörmann S, Ai J, Neuhöfer P, Lesina M, Diakopoulos KN, Ruess D, Treiber M, Witt H, Bassermann F, Halangk W, Steiner JM, Esposito I, Rosendahl J, Schmid RM, Riemann M, Algül H.BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.Gastroenterology. 2016;150(2):499-512.e20. doi: 10.1053/j.gastro.2015.10.017. Pubmed

Kirsten H, Scholz M, Kovacs P, Grallert H, Peters A, Strauch K, Frank J, Rietschel M, Nöthen MM, Witt H, Rosendahl J.Genetic variants of lipase activity in chronic pancreatitis.Gut. 2016;65(1):184-5. doi: 10.1136/gutjnl-2015-309521. Pubmed

Halama A, Horsch M, Kastenmüller G, Möller G, Kumar P, Prehn C, Laumen H, Hauner H, Hrabĕ de Angelis M, Beckers J, Suhre K, Adamski J.Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.Arch Biochem Biophys. 2016;589:93-107. doi: 10.1016/j.abb.2015.09.013. Pubmed

2015

Hoffmeister A, Mayerle J, Beglinger C, Büchler MW, Bufler P, Dathe K, Fölsch UR, Friess H, Izbicki J, Kahl S, Klar E, Keller J, Knoefel WT, Layer P, Loehr M, Meier R, Riemann JF, Rünzi M, Schmid RM, Schreyer A, Tribl B, Werner J, Witt H, Mössner J, Lerch MM; members of the guideline committee.English language version of the S3-consensus guidelines on chronic pancreatitis: Definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis.Z Gastroenterol. 2015;53(12):1447-95. doi: 10.1055/s-0041-107379. Pubmed (pdf-Datei).

Janecke AR, Heinz-Erian P, Yin J, Petersen BS, Franke A, Lechner S, Fuchs I, Melancon S, Uhlig HH, Travis S, Marinier E, Perisic V, Ristic N, Gerner P, Booth IW, Wedenoja S, Baumgartner N, Vodopiutz J, Frechette-Duval MC, De Lafollie J, Persad R, Warner N, Tse CM, Sud K, Zachos NC, Sarker R, Zhu X, Muise AM, Zimmer KP, Witt H, Zoller H, Donowitz M, Müller T.Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea.Hum Mol Genet. 2015;24(23):6614-23. doi: 10.1093/hmg/ddv367. Pubmed (pdf-Datei).

Nakano E, Geisz A, Masamune A, Niihori T, Hamada S, Kume K, Kakuta Y, Aoki Y, Matsubara Y, Ebert K, Ludwig M, Braun M, Groneberg DA, Shimosegawa T, Sahin-Tóth M, Witt H.Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.Am J Physiol Gastrointest Liver Physiol. 2015;309(8):G688-94. doi: 10.1152/ajpgi.00241.2015. Pubmed (pdf-Datei).

Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, Férec C, Drenth JP, Witt H, Rosendahl J; PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators.Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.Gut. 2015;64(9):1426-33. doi: 10.1136/gutjnl-2014-307453. Pubmed

Fiamoncini J, Lima TM, Hirabara SM, Ecker J, Gorjão R, Romanatto T, ELolimy A, Worsch S, Laumen H, Bader B, Daniel H, Curi R.Medium-chain dicarboxylic acylcarnitines as markers of n-3 PUFA-induced peroxisomal oxidation of fatty acids.Mol Nutr Food Res. 2015;59(8):1573-83. doi: 10.1002/mnfr.201400743. Pubmed

Szabó A, Ludwig M, Hegyi E, Szépeová R, Witt H, Sahin-Tóth M.Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.J Biol Chem. 2015;290(28):17282-92. doi: 10.1074/jbc.M114.618439. Pubmed (pdf-Datei).

Fjeld K, Weiss FU, Lasher D, Rosendahl J, Chen JM, Johansson BB, Kirsten H, Ruffert C, Masson E, Steine SJ, Bugert P, Cnop M, Grützmann R, Mayerle J, Mössner J, Ringdal M, Schulz HU, Sendler M, Simon P, Sztromwasser P, Torsvik J, Scholz M, Tjora E, Férec C, Witt H, Lerch MM, Njølstad PR, Johansson S, Molven A.A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.Nat Genet. 2015;47(5):518-522. doi: 10.1038/ng.3249. Pubmed (pdf-Datei).

Diakopoulos KN, Lesina M, Wörmann S, Song L, Aichler M, Schild L, Artati A, Römisch-Margl W, Wartmann T, Fischer R, Kabiri Y, Zischka H, Halangk W, Demir IE, Pilsak C, Walch A, Mantzoros CS, Steiner JM, Erkan M, Schmid RM, Witt H, Adamski J, Algül H.Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes.Gastroenterology. 2015;148(3):626-638.e17. doi: 10.1053/j.gastro.2014.12.003. Pubmed

2014

Prager M, Durmus T, Büttner J, Molnar T, de Jong DJ, Drenth JP, Baumgart DC, Sturm A, Farkas K, Witt H, Büning C.Myosin IXb variants and their pivotal role in maintaining the intestinal barrier: a study in Crohn's disease.Scand J Gastroenterol. 2014;49(10):1191-200. doi: 10.3109/00365521.2014.928903. Pubmed

Krinninger P, Ensenauer R, Ehlers K, Rauh K, Stoll J, Krauss-Etschmann S, Hauner H, Laumen H.Peripheral monocytes of obese women display increased chemokine receptor expression and migration capacity.J Clin Endocrinol Metab. 2014;99(7):2500-9. doi: 10.1210/jc.2013-2611. Pubmed

Ehlers K, Brand T, Bangert A, Hauner H, Laumen H.Postprandial activation of metabolic and inflammatory signalling pathways in human peripheral mononuclear cells.Br J Nutr. 2014;111(12):2167-75. doi: 10.1017/S0007114514000208. Epub 2014 Feb 28. Pubmed

Kretschmer A, Möller G, Lee H, Laumen H, von Toerne C, Schramm K, Prokisch H, Eyerich S, Wahl S, Baurecht H, Franke A, Claussnitzer M, Eyerich K, Teumer A, Milani L, Klopp N, Hauck SM, Illig T, Peters A, Waldenberger M, Adamski J, Reischl E, Weidinger S.A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding.Allergy. 2014;69(5):632-42. doi: 10.1111/all.12394. 2014 Mar 25. Pubmed

Sukalo M, Fiedler A, Guzmán C, Spranger S, Addor MC, McHeik JN, Oltra Benavent M, Cobben JM, Gillis LA, Shealy AG, Deshpande C, Bozorgmehr B, Everman DB, Stattin EL, Liebelt J, Keller KM, Bertola DR, van Karnebeek CD, Bergmann C, Liu Z, Düker G, Rezaei N, Alkuraya FS, Oğur G, Alrajoudi A, Venegas-Vega CA, Verbeek NE, Richmond EJ, Kirbiyik O, Ranganath P, Singh A, Godbole K, Ali FA, Alves C, Mayerle J, Lerch MM, Witt H, Zenker M.Mutations in the human UBR1 gene and the associated phenotypic spectrum.Hum Mutat. 2014;35(5):521-31. doi: 10.1002/humu.22538. Pubmed

Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Müller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Beckers J, Hölter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gómez-Skarmeta JL, Winkelmann J.Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.Genome Res. 2014;24(4):592-603. doi: 10.1101/gr.166751.113. Epub 2014 Mar 18. Pubmed

Wuensch T, Ullrich S, Schulz S, Chamaillard M, Schaltenberg N, Rath E, Goebel U, Sartor RB, Prager M, Büning C, Bugert P, Witt H, Haller D, Daniel H.Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.Inflamm Bowel Dis. 2014;20(4):671-84. doi: 10.1097/01.MIB.0000443336.71488.08. Pubmed

Schnúr A, Beer S, Witt H, Hegyi P, Sahin-Tóth M.Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.Gut. 2014;63(2):337-43. doi: 10.1136/gutjnl-2012-304331. Pubmed (pdf-Datei).

Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H.Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.Cell. 2014;156(1-2):343-58. doi: 10.1016/j.cell.2013.10.058. Pubmed (pdf-Datei).

2013

van der Woerd WL, van Haaften-Visser DY, van de Graaf SF, Férec C, Masson E, Stapelbroek JM, Bugert P, Witt H, Houwen RH.Mutational analysis of ATP8B1 in patients with chronic pancreatitis.PLoS One. 2013;8(11):e80553. doi: 10.1371/journal.pone.0080553. eCollection 2013. Pubmed (pdf-Datei).

Beer S, Zhou J, Szabó A, Keiles S, Chandak GR, Witt H, Sahin-Tóth M.Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.Gut. 2013;62(11):1616-24. doi: 10.1136/gutjnl-2012-303090. Pubmed (pdf-Datei).

Then C, Wahl S, Kirchhofer A, Grallert H, Krug S, Kastenmüller G, Römisch-Margl W, Claussnitzer M, Illig T, Heier M, Meisinger C, Adamski J, Thorand B, Huth C, Peters A, Prehn C, Heukamp I, Laumen H, Lechner A, Hauner H, Seissler J.Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146.PLoS One. 2013;8(10):e78430. doi: 10.1371/journal.pone.0078430. eCollection 2013. Pubmed (pdf-Datei).

Fischer J, Böhm S, Müller T, Witt H, Sarrazin C, Susser S, Migaud P, Schott E, Stewart G, Brodzinski A, Fülöp B, van Bömmel F, George J, Berg T.Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection.PLoS One. 2013;8(10):e77530. doi: 10.1371/journal.pone.0077530. eCollection 2013. Pubmed (pdf-Datei).

Witt H, Beer S, Rosendahl J, Chen JM, Chandak GR, Masamune A, Bence M, Szmola R, Oracz G, Macek M Jr, Bhatia E, Steigenberger S, Lasher D, Bühler F, Delaporte C, Tebbing J, Ludwig M, Pilsak C, Saum K, Bugert P, Masson E, Paliwal S, Bhaskar S, Sobczynska-Tomaszewska A, Bak D, Balascak I, Choudhuri G, Nageshwar Reddy D, Rao GV, Thomas V, Kume K, Nakano E, Kakuta Y, Shimosegawa T, Durko L, Szabó A, Schnúr A, Hegyi P, Rakonczay Z Jr, Pfützer R, Schneider A, Groneberg DA, Braun M, Schmidt H, Witt U, Friess H, Algül H, Landt O, Schuelke M, Krüger R, Wiedenmann B, Schmidt F, Zimmer KP, Kovacs P, Stumvoll M, Blüher M, Müller T, Janecke A, Teich N, Grützmann R, Schulz HU, Mössner J, Keim V, Löhr M, Férec C, Sahin-Tóth M.Variants in CPA1 are strongly associated with early onset chronic pancreatitis.Nat Genet. 2013;45(10):1216-20. doi: 10.1038/ng.2730. Pubmed (pdf-Datei).

Löhr JM, Dinter D, Diehl SJ, Haas SL, Veeser M, Pfützer R, Retter J, Schönberg SO, Düber C, Keim V, Schadendorf D, Witt H.Rapid progression of a splenic aneurysm due to segmental arterial mediolysis: a rare cause of acute pancreatitis.Pancreatology. 2013;13(5):553-6. doi: 10.1016/j.pan.2013.06.001.  Pubmed

Mayerle J, Hoffmeister A, Werner J, Witt H, Lerch MM, Mössner J.Chronic pancreatitis--definition, etiology, investigation and treatment.Dtsch Arztebl Int. 2013;110(22):387-93. doi: 10.3238/arztebl.2013.0387. Pubmed

Rosendahl J, Landt O, Bernadova J, Kovacs P, Teich N, Bödeker H, Keim V, Ruffert C, Mössner J, Kage A, Stumvoll M, Groneberg D, Krüger R, Luck W, Treiber M, Becker M, Witt H.CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?Gut. 2013;62(4):582-92. doi: 10.1136/gutjnl-2011-300645. Pubmed

Mueller K, Quandt J, Marienfeld RB, Weihrich P, Fiedler K, Claussnitzer M, Laumen H, Vaeth M, Berberich-Siebelt F, Serfling E, Wirth T, Brunner C.Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB.Nucleic Acids Res. 2013;41(4):2138-54. doi: 10.1093/nar/gks1349. Epub 2013 Jan 4. Pubmed (pdf-Datei).

Neuhöfer P, Liang S, Einwächter H, Schwerdtfeger C, Wartmann T, Treiber M, Zhang H, Schulz HU, Dlubatz K, Lesina M, Diakopoulos KN, Wörmann S, Halangk W, Witt H, Schmid RM, Algül H.Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A.Gastroenterology. 2013;144(1):192-201. doi: 10.1053/j.gastro.2012.09.058. Pubmed

2012 

Hoffmeister A, Mayerle J, Dathe K, Mössner J, Lerch MM; Mitglieder der Leitlinienkommission.[Method report to the S3 guideline chronic pancreatitis: definition, etiology, diagnostics and conservative, interventional endoscopic and surgical therapy of the chronic pancreatitis].Z Gastroenterol. 2012;50(11):1225-36. doi: 10.1055/s-0032-1325447. Pubmed

Chronic Pancreatitis German Society of Digestive and Metabolic Diseases (DGVS), Hoffmeister A, Mayerle J, Beglinger C, Büchler MW, Bufler P, Dathe K, Fölsch UR, Friess H, Izbicki J, Kahl S, Klar E, Keller J, Knoefel WT, Layer P, Loehr M, Meier R, Riemann JF, Rünzi M, Schmid RM, Schreyer A, Tribl B, Werner J, Witt H, Mössner J, Lerch MM.[S3-Consensus guidelines on definition, etiology, diagnosis and medical, endoscopic and surgical management of chronic pancreatitis German Society of Digestive and Metabolic Diseases (DGVS)].Z Gastroenterol. 2012;50(11):1176-224. doi: 10.1055/s-0032-1325479. German. Pubmed.

Fischer J, Böhm S, Scholz M, Müller T, Witt H, George J, Sarrazin C, Susser S, Schott E, Suppiah V, Booth DR, Stewart GJ, van Bömmel F, Brodzinski A, Fülöp B, Migaud P, Berg T.Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection.Hepatology. 2012;55(6):1700-10. doi: 10.1002/hep.25582. Pubmed

Weis S, Jesinghaus M, Kovacs P, Schleinitz D, Schober R, Ruffert C, Herms M, Wittenburg H, Stumvoll M, Blüher M, Grützmann R, Schulz HU, Keim V, Mössner J, Bugert P, Witt H, Drenth JP, Krohn K, Rosendahl J.Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis.PLoS One. 2012;7(5):e37981. doi: 10.1371/journal.pone.0037981. Pubmed (pdf-Datei).

Löhr JM, Schneider A, Diehl SJ, Witt H.Opie's hypothesis revisited: acute pancreatitis due to bile reflux into the pancreas.Pancreatology. 2012;12(1):39-40. doi: 10.1016/j.pan.2011.12.001. Pubmed

Rosendahl J, Tönjes A, Schleinitz D, Kovacs P, Wiegand J, Ruffert C, Jesinghaus M, Schober R, Herms M, Grützmann R, Schulz HU, Stickel F, Werner J, Bugert P, Blüher M, Stumvoll M, Böhm S, Berg T, Wittenburg H, Mössner J, te Morsche R, Derikx M, Keim V, Witt H, Drenth JP.A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis.PLoS One. 2012;7(1):e29433. doi: 10.1371/journal.pone.0029433. Pubmed (pdf-Datei).

2011

Krinninger P, Brunner C, Ruiz PA, Schneider E, Marx N, Foryst-Ludwig A, Kintscher U, Haller D, Laumen H, Hauner H.Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration.Am J Physiol Endocrinol Metab. 2011;300(2):E304-11. doi: 10.1152/ajpendo.00143.2010. Pubmed  (pdf-Datei).

Boulling A, Witt H, Chandak GR, Masson E, Paliwal S, Bhaskar S, Reddy DN, Cooper DN, Chen JM, Férec C.Assessing the pathological relevance of SPINK1 promoter variants.Eur J Hum Genet. 2011;19(10):1066-73. doi: 10.1038/ejhg.2011.79. Pubmed (pdf-Datei).

Steiner B, Rosendahl J, Witt H, Teich N, Keim V, Schulz HU, Pfützer R, Löhr M, Gress TM, Nickel R, Landt O, Koudova M, Macek M Jr, Farre A, Casals T, Desax MC, Gallati S, Gomez-Lira M, Audrezet MP, Férec C, des Georges M, Claustres M, Truninger K.Common CFTR haplotypes and susceptibility to chronic pancreatitis and congenital bilateral absence of the vas deferens.Hum Mutat. 2011;32(8):912-20. doi: 10.1002/humu.21511. Pubmed

Witt H.New modifier loci in cystic fibrosis.Nat Genet. 2011;43(6):508-9. doi: 10.1038/ng.844. Pubmed

Tiller G, Laumen H, Fischer-Posovszky P, Finck A, Skurk T, Keuper M, Brinkmann U, Wabitsch M, Link D, Hauner H.LIGHT (TNFSF14) inhibits adipose differentiation without affecting adipocyte metabolism.Int J Obes (Lond). 2011;35(2):208-16. doi: 10.1038/ijo.2010.126. Pubmed

2010

Rosendahl J, Teich N, Kovacs P, Szmola R, Blüher M, Gress TM, Hoffmeister A, Keim V, Löhr M, Mössner J, Nickel R, Ockenga J, Pfützer R, Schulz HU, Stumvoll M, Wittenburg H, Sahin-Tóth M, Witt H.Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis.Pancreatology. 2010;10(2-3):243-9. doi: 10.1159/000243769. Pubmed (pdf-Datei).

van der Doef HP, Slieker MG, Staab D, Alizadeh BZ, Seia M, Colombo C, van der Ent CK, Nickel R, Witt H, Houwen RH.Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis.J Pediatr Gastroenterol Nutr. 2010;50(3):347-9. doi: 10.1097/MPG.0b013e3181afce6c. Pubmed

Witt H.Genetics of pancreatitis: a guide for clinicians.Dig Dis. 2010;28(6):702-8. doi: 10.1159/000324276. Review. Pubmed

Witt H, Rosendahl J, te Morsche RH, Santhosh S, Chacko A, Schulz HU, Landt O, Teich N, Keim V, Mössner J, Gress TM, Ockenga J, Schmidt H, Kovacs P, Blüher M, Stumvoll M, Kage A, Groneberg DA, Jansen JB, Nickel R, Drenth JP.Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis.Pancreas. 2010;39(2):188-92. doi: 10.1097/MPA.0b013e3181bd94ae. Pubmed

2009

Hucl T, Kylanpää ML, Künzli B, Witt H, Lempinen M, Schneider A, Kemppainen E, Löhr M, Haas SL, Friess H, Ockenga J, Rosendahl J, Schulz HU, Gress T, Singer MV, Pfützer RH. Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis. Eur J Gastroenterol Hepatol. 2009 Mar 20. [Epub ahead of print] PubMed

Ockenga J, Strunck S, Post C, Schulz HU, Halangk J, Pfützer RH, Löhr M, Oettle H, Kage A, Rosendahl J, Keim V, Drenth JP, Jansen JB, Lochs H, Witt H. The Role of Epoxide Hydrolase Y113H Gene Variant in Pancreatic Diseases. Pancreas. 2009 Mar 12. [Epub ahead of print] PubMed

Zitnik SE, Rüschendorf F, Müller S, Sengler C, Lee YA, Griffioen RW, Meglio P, Wahn U, Witt H, Nickel R. IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis. Pediatr Allergy Immunol. 2009 Jan 31. [Epub ahead of print] PubMed

Beier KC, Humberdros S, Witt H, Illi S, Rüschendorf F, Nickel R, Lee YA, Lau S, Wahn U, Hamelmann E. ICOS-gene variants are not associated with atopic disease susceptibility in European children. Pediatr Allergy Immunol. 2009 Sep 26. [Epub ahead of print] PubMed

Sundaresan S, Chacko A, Dutta AK, Bhatia E, Witt H, Te Morsche RH, Jansen JB, Drenth JP. Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. Pancreatology. 2009;9:145-149. PubMed

Rónai Z, Witt H, Rickards O, Destro-Bisol G, Bradbury AR, Sahin-Tóth M. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). Biochem J. 2009;418:155-161. PubMed (pdf-Datei).

Laumen H et al. Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data. Diabetes. 2009;58(4):984-91. doi: 10.2337/db07-1646. Pubmed (pdf-Datei).

2008

Halangk J, Sarrazin C, Neumann K, Puhl G, Müller T, Teuber G, Klinker H, Hinrichsen H, Buggisch P, Landt O, Weich V, Bergk A, Wiedenmann B, Neuhaus P, Berg T, Witt H. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). J Hepatol. 2008;49:339-345. PubMed

O'Reilly DA, Witt H, Rahman SH, Schulz HU, Sargen K, Kage A, Cartmell MT, Landt O, Larvin M, Demaine AG, McMahon MJ, Becker M, Kingsnorth AN. The SPINK1 N34S variant is associated with acute pancreatitis. Eur J Gastroenterol Hepatol. 2008;20:726-731. PubMed

Witt H, Bhatia E. Genetic aspects of tropical calcific pancreatitis. Rev Endocr Metab Disord. 2008;9:213-226. Review. PubMed (pdf-Datei)

Von Hahn T, Halangk J, Witt H, Neumann K, Müller T, Puhl G, Neuhaus P, Nickel R, Beuers U, Wiedenmann B, Berg T. Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease. Scand J Gastroenterol. 2008;43:584-592. PubMed

Santhosh S, Witt H, te Morsche RH, Nemoda Z, Molnár T, Pap A, Jansen JB, Drenth JP. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. Pancreas. 2008;36:317-320. PubMed

Büning C, Schmidt HH, Molnár T, Drenth JP, Fiedler T, Gentz E, Todorov T, Baumgart DC, Sturm A, Nagy F, Lonovics J, de Jong DJ, Landt O, Kage A, Nickel R, Büttner J, Lochs H, Witt H. No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts. Inflamm Bowel Dis. 2008;14:332-337. PubMed

Schott E, Witt H, Neumann K, Bergk A, Halangk J, Weich V, Müller T, Puhl G, Wiedenmann B, Berg T. Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. J Viral Hepat. 2008;15:71-78. PubMed

Rosendahl J, Witt H, Szmola R, Bhatia E, Ozsvári B, Landt O, Schulz HU, Gress TM, Pfützer R, Löhr M, Kovacs P, Blüher M, Stumvoll M, Choudhuri G, Hegyi P, te Morsche RH, Drenth JP, Truninger K, Macek M Jr, Puhl G, Witt U, Schmidt H, Büning C, Ockenga J, Kage A, Groneberg DA, Nickel R, Berg T, Wiedenmann B, Bödeker H, Keim V, Mössner J, Teich N, Sahin-Tóth M. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet. 2008;40:78-82. PubMed (pdf-Datei)

Browning BL, Annese V, Barclay ML, Bingham SA, Brand S, Büning C, Castro M, Cucchiara S, Dallapiccola B, Drummond H, Ferguson LR, Ferraris A, Fisher SA, Gearry RB, Glas J, Henckaerts L, Huebner C, Knafelz D, Lakatos L, Lakatos PL, Latiano A, Liu X, Mathew C, Müller-Myhsok B, Newman WG, Nimmo ER, Noble CL, Palmieri O, Parkes M, Petermann I, Rutgeerts P, Satsangi J, Shelling AN, Siminovitch KA, Török HP, Tremelling M, Vermeire S, Valvano MR, Witt H. Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. J Med Genet. 2008;45:36-42. PubMed

te Morsche RH, Drenth JP, Truninger K, Schulz HU, Kage A, Landt O, Verlaan M, Rosendahl J, Macek M Jr, Jansen JB, Witt H. UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls. Pharmacogenomics J. 2008;8:34-41. PubMed

2007

Baumgart DC, Büning C, Geerdts L, Schmidt HH, Genschel J, Fiedler T, Gentz E, Molnár T, Nagy F, Lonovics J, Lochs H, Wiedenmann B, Nickel R, Witt H, Dignass A. The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease. Digestion. 2007;76:196-202. PubMed 

Schott E, Witt H, Pascu M, van Boemmel F, Weich V, Bergk A, Halangk J, Müller T, Puhl G, Wiedenmann B, Berg T. Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease. Eur J Gastroenterol Hepatol. 2007;19:947-951. PubMed

Büning C, Schmidt HH, Molnar T, De Jong DJ, Fiedler T, Bühner S, Sturm A, Baumgart DC, Nagy F, Lonovics J, Drenth JP, Landt O, Nickel R, Büttner J, Lochs H, Witt H. Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. Aliment Pharmacol Ther. 2007;26:1025-1033. PubMed (pdf-Datei).

Hucl T, Kylanpää-Bäck ML, Witt H, Künzli B, Lempinen M, Schneider A, Kemppainen E, Löhr M, Friess H, Ockenga J, Rosendahl J, Schulz HU, Gress T, Singer MV, Pfützer RH. HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma. Genet Med. 2007;9:479-483. PubMed

Müller S, Keil T, Grüber C, Zitnik SE, Lau S, Wahn U, Witt H, Nickel R. MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort. Pediatr Allergy Immunol. 2007;18:665-670. PubMed

Büning C, Durmus T, Molnar T, de Jong DJ, Drenth JPH, Fiedler T, Gentz E, Todorov T, Haas V, Buhner S, Sturm A, Baumgart DC, Nagy F, Lonovics J, Landt O, Kage A, Büning H, Nickel R, Büttner J, Lochs H, Schmidt HHJ, Witt H. A study in three European IBD cohorts confirms that the ATG16L1 c.898A>G (p.Thr300Ala) variant is a susceptibility factor for Crohn’s disease. Journal of Crohn's and Colitis 2007;1:70-76.PubMed

Schott E, Witt H, Neumann K, Taube S, Oh DY, Schreier E, Vierich S, Puhl G, Bergk A, Halangk J, Weich V, Wiedenmann B, Berg T. A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection. J Hepatol. 2007;47:203-211. PubMed

Witt H, Apte MV, Keim V, Wilson JS. Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology. 2007;132:1557-1573. Review. PubMed (pdf-Datei)

Király O, Boulling A, Witt H, Le Maréchal C, Chen JM, Rosendahl J, Battaggia C, Wartmann T, Sahin-Tóth M, Férec C. Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. Hum Mutat. 2007;28:469-476. PubMed (pdf-Datei).

Schott E, Witt H, Hinrichsen H, Neumann K, Weich V, Bergk A, Halangk J, Müller T, Tinjala S, Puhl G, Neuhaus P, Wiedenmann B, Berg T. Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection. J Hepatol. 2007;46:372-380. PubMed

Markart P, Ruppert C, Wygrecka M, Schmidt R, Korfei M, Harbach H, Theruvath I, Pison U, Seeger W, Guenther A, Witt H. Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias. Eur Respir J. 2007;29:134-137. PubMed (pdf-Datei).

2006 

Treiber M, Schulz HU, Landt O, Drenth JP, Castellani C, Real FX, Akar N, Ammann RW, Bargetzi M, Bhatia E, Demaine AG, Battagia C, Kingsnorth A, O'Reilly D, Truninger K, Koudova M, Spicak J, Cerny M, Menzel HJ, Moral P, Pignatti PF, Romanelli MG, Rickards O, De Stefano GF, Zarnescu NO, Choudhuri G, Sikora SS, Jansen JB, Weiss FU, Pietschmann M, Teich N, Gress TM, Ockenga J, Schmidt H, Kage A, Halangk J, Rosendahl J, Groneberg DA, Nickel R, Witt H. Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer. J Mol Med. 2006;84:1015-1022. PubMed

Witt H, Sahin-Tóth M, Landt O, Chen JM, Kähne T, Drenth JP, Kukor Z, Szepessy E, Halangk W, Dahm S, Rohde K, Schulz HU, Le Maréchal C, Akar N, Ammann RW, Truninger K, Bargetzi M, Bhatia E, Castellani C, Cavestro GM, Cerny M, Destro-Bisol G, Spedini G, Eiberg H, Jansen JB, Koudova M, Rausova E, Macek M Jr, Malats N, Real FX, Menzel HJ, Moral P, Galavotti R, Pignatti PF, Rickards O, Spicak J, Zarnescu NO, Böck W, Gress TM, Friess H, Ockenga J, Schmidt H, Pfützer R, Löhr M, Simon P, Weiss FU, Lerch MM, Teich N, Keim V, Berg T, Wiedenmann B, Luck W, Groneberg DA, Becker M, Keil T, Kage A, Bernardova J, Braun M, Güldner C, Halangk J, Rosendahl J, Witt U, Treiber M, Nickel R, Férec C. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet. 2006;38:668-673. PubMed (pdf-Datei)

Büning C, Geerdts L, Fiedler T, Gentz E, Pitre G, Reuter W, Luck W, Bühner S, Molnár T, Nagy F, Lonovics J, Dignass A, Landt O, Nickel R, Genschel J, Lochs H, Schmidt HH, Witt H. DLG5 variants in inflammatory bowel disease. Am J Gastroenterol. 2006;101:786-792. PubMed

1999-2005

Frerking I, Sengler C, Günther A, Walmrath HD, Stevens P, Witt H, Landt O, Pison U, Nickel R. Evaluation of the -26G>A CC16 polymorphism in acute respiratory distress syndrome. Crit Care Med. 2005;33:2404-2406. PubMed

Perrot A, Schmidt-Traub H, Hoffmann B, Prager M, Bit-Avragim N, Rudenko RI, Usupbaeva DA, Kabaeva Z, Imanov B, Mirrakhimov MM, Witt H, Dietz R, Wycisk A, Tendera M, Gessner R, Osterziel KJ. Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy. J Mol Med 2005;83:468-477 (erratum: J Mol Med 2005;83:837). PubMed

Verlaan M, Drenth JP, Truninger K, Koudova M, Schulz HU, Bargetzi M, Künzli B, Friess H, Cerny M, Kage A, Landt O, te Morsche RH, Rosendahl J, Luck W, Nickel R, Halangk J, Becker M, Macek M Jr, Jansen JB, Witt H. Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. J Med Genet. 2005;42:e62. PubMed (pdf-Datei).

Müller T, Mas-Marques A, Sarrazin C, Wiese M, Halangk J, Witt H, Ahlenstiel G, Spengler U, Goebel U, Wiedenmann B, Schreier E, Berg T. Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. J Hepatol. 2004;41:652-658. PubMed

Büning C, Halangk J, Dignass A, Ockenga J, Deindl P, Nickel R, Genschel J, Landt O, Lochs H, Schmidt H, Witt H. Keratin 8 Y54H and G62C mutations are not associated with inflammatory bowel disease. Dig Liver Dis. 2004;36:388-391. PubMed

Halangk J, Berg T, Puhl G, Mueller T, Nickel R, Kage A, Landt O, Luck W, Wiedenmann B, Neuhaus P, Witt H. Keratin 8 Y54H and G62C mutations are not associated with liver disease. J Med Genet. 2004;41:e92. PubMed (pdf-Datei).

Groneberg DA, Witt H, Adcock IM, Hansen G, Springer J. Smads as intracellular mediators of airway inflammation. Exp Lung Res. 2004;30:223-250. Review. PubMed

Belkind-Gerson J, Fernandez-Peters A, Furnes R, Oliver M, Perrault J, Robertson M, Witt H; Latin American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Pancreatic disorders and cystic fibrosis: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2004;39 Suppl 2:S688-694. Review. PubMed

Witt H, Neumann LM, Grollmuss O, Luck W, Becker M. Prenatal diagnosis of Alagille syndrome. J Pediatr Gastroenterol Nutr. 2004;38:105-106. PubMed

Müller T, Geßner R, Sarrazin C, Graf C, Halangk J, Witt H, Köttgen E, Wiedenmann B, Berg T. Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1. Hepatology. 2003;38:1592. PubMed

Bhatia E, Kordonouri O, Balasubramanium K, Rajeswari J, Landt O, Simon P, Lerch MM, Witt H. Absence of association between SPINK1 trypsin inhibitor mutations and Type 1 or 2 diabetes mellitus in India and Germany. Diabetologia. 2003;46:1710-1711. PubMed

Beranek H, Teich N, Witt H, Schulz HU, Mössner J, Keim V. Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis. Eur J Gastroenterol Hepatol. 2003;15:1223-1227. PubMed

Keim V, Witt H, Bauer N, Bödeker H, Rosendahl J, Teich N, Mössner J. The course of genetically determined chronic pancreatitis. JOP. 2003;4:146-154. PubMed (pdf-Datei).

Weiss FU, Simon P, Witt H, Mayerle J, Hlouschek V, Zimmer KP, Schnekenburger J, Domschke W, Neoptolemos JP, Lerch MM. SPINK1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations. J Med Genet. 2003;40:e40. PubMed (pdf-Datei).

Witt H. Chronic pancreatitis and cystic fibrosis. Gut. 2003;52 Suppl 2:ii31-41. Review. PubMed (pdf-Datei).

Teich N, Schulz HU, Witt H, Böhmig M, Keim V. N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer. Pancreatology. 2003;3:67-68. PubMed

Müller T, van de Sluis B, Zhernakova A, van Binsbergen E, Janecke AR, Bavdekar A, Pandit A, Weirich-Schwaiger H, Witt H, Ellemunter H, Deutsch J, Denk H, Müller W, Sternlieb I, Tanner MS, Wijmenga C. The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. J Hepatol. 2003;38:164-168. PubMed

Bhatia E, Choudhuri G, Sikora SS, Landt O, Kage A, Becker M, Witt H. Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. Gastroenterology. 2002;123:1020-1025. PubMed

Truninger K, Witt H, Köck J, Kage A, Seifert B, Ammann RW, Blum HE, Becker M. Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis. Am J Gastroenterol. 2002;97:1133-1137. PubMed

Witt H. The SPINK in chronic pancreatitis: similar finds, different minds. Gut. 2002;50:590-591. PubMed (pdf-Datei).

Witt H, Kage A, Luck W, Becker M. Alpha1-antitrypsin genotypes in patients with chronic pancreatitis. Scand J Gastroenterol. 2002;37:356-359. PubMed

Witt H, Becker M. Genetics of chronic pancreatitis. J Pediatr Gastroenterol Nutr. 2002;34:125-136. Review. PubMed

Witt H. Gene mutations in children with chronic pancreatitis. Pancreatology. 2001;1:432-438. Review. PubMed

Truninger K, Ammann RW, Blum HE, Witt H. Genetic aspects of chronic pancreatitis: insights into aetiopathogenesis and clinical implications. Swiss Med Wkly. 2001;131:565-574. Review. PubMed

Witt H, Landt O. Rapid detection of the Wilson's disease H1069Q mutation by melting curve analysis with the LightCycler. Clin Chem Lab Med. 2001;39:953-955. PubMed

Witt H, Simon P, Lerch MM. [Genetic aspects of chronic pancreatitis]. Dtsch Med Wochenschr. 2001;126:988-993. Review. PubMed

Witt H, Luck W, Becker M, Böhmig M, Kage A, Truninger K, Ammann RW, O'Reilly D, Kingsnorth A, Schulz HU, Halangk W, Kielstein V, Knoefel WT, Teich N, Keim V. Mutation in the SPINK1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis. JAMA. 2001;285:2716-2717. PubMed

Witt H, Hennies HC, Becker M. SPINK1 mutations in chronic pancreatitis. Gastroenterology. 2001;120:1060-1061. PubMed

Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000;25:213-216. PubMed

Maier RF, Witt H, Bührer C, Mönch E, Köttgen E. HFE gene mutation and transferrin saturation in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 1999;81:F144-145. PubMed (pdf-Datei).

Witt H, Luck W, Becker M. A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology. 1999;117:7-10. PubMed