Persönlicher Status und Werkzeuge

Sprachwahl

Publikationen

2009

Hucl T, Kylanpää ML, Künzli B, Witt H, Lempinen M, Schneider A, Kemppainen E, Löhr M, Haas SL, Friess H, Ockenga J, Rosendahl J, Schulz HU, Gress T, Singer MV, Pfützer RH. Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis. Eur J Gastroenterol Hepatol. 2009 Mar 20. [Epub ahead of print] PubMed

Ockenga J, Strunck S, Post C, Schulz HU, Halangk J, Pfützer RH, Löhr M, Oettle H, Kage A, Rosendahl J, Keim V, Drenth JP, Jansen JB, Lochs H, Witt H. The Role of Epoxide Hydrolase Y113H Gene Variant in Pancreatic Diseases. Pancreas. 2009 Mar 12. [Epub ahead of print] PubMed

Zitnik SE, Rüschendorf F, Müller S, Sengler C, Lee YA, Griffioen RW, Meglio P, Wahn U, Witt H, Nickel R. IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis. Pediatr Allergy Immunol. 2009 Jan 31. [Epub ahead of print] PubMed

Beier KC, Humberdros S, Witt H, Illi S, Rüschendorf F, Nickel R, Lee YA, Lau S, Wahn U, Hamelmann E. ICOS-gene variants are not associated with atopic disease susceptibility in European children. Pediatr Allergy Immunol. 2009 Sep 26. [Epub ahead of print] PubMed

Sundaresan S, Chacko A, Dutta AK, Bhatia E, Witt H, Te Morsche RH, Jansen JB, Drenth JP. Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. Pancreatology. 2009;9:145-149. PubMed

Rónai Z, Witt H, Rickards O, Destro-Bisol G, Bradbury AR, Sahin-Tóth M. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). Biochem J. 2009;418:155-161. PubMed

2008

Halangk J, Sarrazin C, Neumann K, Puhl G, Müller T, Teuber G, Klinker H, Hinrichsen H, Buggisch P, Landt O, Weich V, Bergk A, Wiedenmann B, Neuhaus P, Berg T, Witt H. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). J Hepatol. 2008;49:339-345. PubMed

O'Reilly DA, Witt H, Rahman SH, Schulz HU, Sargen K, Kage A, Cartmell MT, Landt O, Larvin M, Demaine AG, McMahon MJ, Becker M, Kingsnorth AN. The SPINK1 N34S variant is associated with acute pancreatitis. Eur J Gastroenterol Hepatol. 2008;20:726-731. PubMed

Witt H, Bhatia E. Genetic aspects of tropical calcific pancreatitis. Rev Endocr Metab Disord. 2008;9:213-226. Review. PubMed Artikel (pdf-Datei)

Von Hahn T, Halangk J, Witt H, Neumann K, Müller T, Puhl G, Neuhaus P, Nickel R, Beuers U, Wiedenmann B, Berg T. Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease. Scand J Gastroenterol. 2008;43:584-592. PubMed

Santhosh S, Witt H, te Morsche RH, Nemoda Z, Molnár T, Pap A, Jansen JB, Drenth JP. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. Pancreas. 2008;36:317-320. PubMed

Büning C, Schmidt HH, Molnár T, Drenth JP, Fiedler T, Gentz E, Todorov T, Baumgart DC, Sturm A, Nagy F, Lonovics J, de Jong DJ, Landt O, Kage A, Nickel R, Büttner J, Lochs H, Witt H. No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts. Inflamm Bowel Dis. 2008;14:332-337. PubMed

Schott E, Witt H, Neumann K, Bergk A, Halangk J, Weich V, Müller T, Puhl G, Wiedenmann B, Berg T. Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. J Viral Hepat. 2008;15:71-78. PubMed

Rosendahl J, Witt H, Szmola R, Bhatia E, Ozsvári B, Landt O, Schulz HU, Gress TM, Pfützer R, Löhr M, Kovacs P, Blüher M, Stumvoll M, Choudhuri G, Hegyi P, te Morsche RH, Drenth JP, Truninger K, Macek M Jr, Puhl G, Witt U, Schmidt H, Büning C, Ockenga J, Kage A, Groneberg DA, Nickel R, Berg T, Wiedenmann B, Bödeker H, Keim V, Mössner J, Teich N, Sahin-Tóth M. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet. 2008;40:78-82. PubMed Artikel (pdf-Datei)

Browning BL, Annese V, Barclay ML, Bingham SA, Brand S, Büning C, Castro M, Cucchiara S, Dallapiccola B, Drummond H, Ferguson LR, Ferraris A, Fisher SA, Gearry RB, Glas J, Henckaerts L, Huebner C, Knafelz D, Lakatos L, Lakatos PL, Latiano A, Liu X, Mathew C, Müller-Myhsok B, Newman WG, Nimmo ER, Noble CL, Palmieri O, Parkes M, Petermann I, Rutgeerts P, Satsangi J, Shelling AN, Siminovitch KA, Török HP, Tremelling M, Vermeire S, Valvano MR, Witt H. Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. J Med Genet. 2008;45:36-42. PubMed

te Morsche RH, Drenth JP, Truninger K, Schulz HU, Kage A, Landt O, Verlaan M, Rosendahl J, Macek M Jr, Jansen JB, Witt H. UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls. Pharmacogenomics J. 2008;8:34-41. PubMed

2007

Baumgart DC, Büning C, Geerdts L, Schmidt HH, Genschel J, Fiedler T, Gentz E, Molnár T, Nagy F, Lonovics J, Lochs H, Wiedenmann B, Nickel R, Witt H, Dignass A. The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease. Digestion. 2007;76:196-202. PubMed 

Schott E, Witt H, Pascu M, van Boemmel F, Weich V, Bergk A, Halangk J, Müller T, Puhl G, Wiedenmann B, Berg T. Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease. Eur J Gastroenterol Hepatol. 2007;19:947-951. PubMed

Büning C, Schmidt HH, Molnar T, De Jong DJ, Fiedler T, Bühner S, Sturm A, Baumgart DC, Nagy F, Lonovics J, Drenth JP, Landt O, Nickel R, Büttner J, Lochs H, Witt H. Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. Aliment Pharmacol Ther. 2007;26:1025-1033. PubMed

Hucl T, Kylanpää-Bäck ML, Witt H, Künzli B, Lempinen M, Schneider A, Kemppainen E, Löhr M, Friess H, Ockenga J, Rosendahl J, Schulz HU, Gress T, Singer MV, Pfützer RH. HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma. Genet Med. 2007;9:479-483. PubMed

Müller S, Keil T, Grüber C, Zitnik SE, Lau S, Wahn U, Witt H, Nickel R. MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort. Pediatr Allergy Immunol. 2007;18:665-670. PubMed

Büning C, Durmus T, Molnar T, de Jong DJ, Drenth JPH, Fiedler T, Gentz E, Todorov T, Haas V, Buhner S, Sturm A, Baumgart DC, Nagy F, Lonovics J, Landt O, Kage A, Büning H, Nickel R, Büttner J, Lochs H, Schmidt HHJ, Witt H. A study in three European IBD cohorts confirms that the ATG16L1 c.898A>G (p.Thr300Ala) variant is a susceptibility factor for Crohn’s disease. Journal of Crohn's and Colitis 2007;1:70-76.

Schott E, Witt H, Neumann K, Taube S, Oh DY, Schreier E, Vierich S, Puhl G, Bergk A, Halangk J, Weich V, Wiedenmann B, Berg T. A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection. J Hepatol. 2007;47:203-211. PubMed

Witt H, Apte MV, Keim V, Wilson JS. Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology. 2007;132:1557-1573. Review. PubMed Artikel (pdf-Datei)

Király O, Boulling A, Witt H, Le Maréchal C, Chen JM, Rosendahl J, Battaggia C, Wartmann T, Sahin-Tóth M, Férec C. Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. Hum Mutat. 2007;28:469-476. PubMed

Schott E, Witt H, Hinrichsen H, Neumann K, Weich V, Bergk A, Halangk J, Müller T, Tinjala S, Puhl G, Neuhaus P, Wiedenmann B, Berg T. Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection. J Hepatol. 2007;46:372-380. PubMed

Markart P, Ruppert C, Wygrecka M, Schmidt R, Korfei M, Harbach H, Theruvath I, Pison U, Seeger W, Guenther A, Witt H. Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias. Eur Respir J. 2007;29:134-137. PubMed

2006 

Treiber M, Schulz HU, Landt O, Drenth JP, Castellani C, Real FX, Akar N, Ammann RW, Bargetzi M, Bhatia E, Demaine AG, Battagia C, Kingsnorth A, O'Reilly D, Truninger K, Koudova M, Spicak J, Cerny M, Menzel HJ, Moral P, Pignatti PF, Romanelli MG, Rickards O, De Stefano GF, Zarnescu NO, Choudhuri G, Sikora SS, Jansen JB, Weiss FU, Pietschmann M, Teich N, Gress TM, Ockenga J, Schmidt H, Kage A, Halangk J, Rosendahl J, Groneberg DA, Nickel R, Witt H. Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer. J Mol Med. 2006;84:1015-1022. PubMed

Witt H, Sahin-Tóth M, Landt O, Chen JM, Kähne T, Drenth JP, Kukor Z, Szepessy E, Halangk W, Dahm S, Rohde K, Schulz HU, Le Maréchal C, Akar N, Ammann RW, Truninger K, Bargetzi M, Bhatia E, Castellani C, Cavestro GM, Cerny M, Destro-Bisol G, Spedini G, Eiberg H, Jansen JB, Koudova M, Rausova E, Macek M Jr, Malats N, Real FX, Menzel HJ, Moral P, Galavotti R, Pignatti PF, Rickards O, Spicak J, Zarnescu NO, Böck W, Gress TM, Friess H, Ockenga J, Schmidt H, Pfützer R, Löhr M, Simon P, Weiss FU, Lerch MM, Teich N, Keim V, Berg T, Wiedenmann B, Luck W, Groneberg DA, Becker M, Keil T, Kage A, Bernardova J, Braun M, Güldner C, Halangk J, Rosendahl J, Witt U, Treiber M, Nickel R, Férec C. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet. 2006;38:668-673. PubMed Artikel (pdf-Datei)

Büning C, Geerdts L, Fiedler T, Gentz E, Pitre G, Reuter W, Luck W, Bühner S, Molnár T, Nagy F, Lonovics J, Dignass A, Landt O, Nickel R, Genschel J, Lochs H, Schmidt HH, Witt H. DLG5 variants in inflammatory bowel disease. Am J Gastroenterol. 2006;101:786-792. PubMed

1999-2005

Frerking I, Sengler C, Günther A, Walmrath HD, Stevens P, Witt H, Landt O, Pison U, Nickel R. Evaluation of the -26G>A CC16 polymorphism in acute respiratory distress syndrome. Crit Care Med. 2005;33:2404-2406. PubMed

Perrot A, Schmidt-Traub H, Hoffmann B, Prager M, Bit-Avragim N, Rudenko RI, Usupbaeva DA, Kabaeva Z, Imanov B, Mirrakhimov MM, Witt H, Dietz R, Wycisk A, Tendera M, Gessner R, Osterziel KJ. Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy. J Mol Med 2005;83:468-477 (erratum: J Mol Med 2005;83:837).

Verlaan M, Drenth JP, Truninger K, Koudova M, Schulz HU, Bargetzi M, Künzli B, Friess H, Cerny M, Kage A, Landt O, te Morsche RH, Rosendahl J, Luck W, Nickel R, Halangk J, Becker M, Macek M Jr, Jansen JB, Witt H. Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. J Med Genet. 2005;42:e62. PubMed

Müller T, Mas-Marques A, Sarrazin C, Wiese M, Halangk J, Witt H, Ahlenstiel G, Spengler U, Goebel U, Wiedenmann B, Schreier E, Berg T. Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. J Hepatol. 2004;41:652-658. PubMed

Büning C, Halangk J, Dignass A, Ockenga J, Deindl P, Nickel R, Genschel J, Landt O, Lochs H, Schmidt H, Witt H. Keratin 8 Y54H and G62C mutations are not associated with inflammatory bowel disease. Dig Liver Dis. 2004;36:388-391. PubMed

Halangk J, Berg T, Puhl G, Mueller T, Nickel R, Kage A, Landt O, Luck W, Wiedenmann B, Neuhaus P, Witt H. Keratin 8 Y54H and G62C mutations are not associated with liver disease. J Med Genet. 2004;41:e92. PubMed

Groneberg DA, Witt H, Adcock IM, Hansen G, Springer J. Smads as intracellular mediators of airway inflammation. Exp Lung Res. 2004;30:223-250. Review. PubMed

Belkind-Gerson J, Fernandez-Peters A, Furnes R, Oliver M, Perrault J, Robertson M, Witt H; Latin American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Pancreatic disorders and cystic fibrosis: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2004;39 Suppl 2:S688-694. Review. PubMed

Witt H, Neumann LM, Grollmuss O, Luck W, Becker M. Prenatal diagnosis of Alagille syndrome. J Pediatr Gastroenterol Nutr. 2004;38:105-106. PubMed

Müller T, Geßner R, Sarrazin C, Graf C, Halangk J, Witt H, Köttgen E, Wiedenmann B, Berg T. Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1. Hepatology. 2003;38:1592. PubMed

Bhatia E, Kordonouri O, Balasubramanium K, Rajeswari J, Landt O, Simon P, Lerch MM, Witt H. Absence of association between SPINK1 trypsin inhibitor mutations and Type 1 or 2 diabetes mellitus in India and Germany. Diabetologia. 2003;46:1710-1711. PubMed

Beranek H, Teich N, Witt H, Schulz HU, Mössner J, Keim V. Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis. Eur J Gastroenterol Hepatol. 2003;15:1223-1227. PubMed

Keim V, Witt H, Bauer N, Bödeker H, Rosendahl J, Teich N, Mössner J. The course of genetically determined chronic pancreatitis. JOP. 2003;4:146-154. PubMed

Weiss FU, Simon P, Witt H, Mayerle J, Hlouschek V, Zimmer KP, Schnekenburger J, Domschke W, Neoptolemos JP, Lerch MM. SPINK1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations. J Med Genet. 2003;40:e40. PubMe

Witt H. Chronic pancreatitis and cystic fibrosis. Gut. 2003;52 Suppl 2:ii31-41. Review. PubMed

Teich N, Schulz HU, Witt H, Böhmig M, Keim V. N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer. Pancreatology. 2003;3:67-68. PubMed

Müller T, van de Sluis B, Zhernakova A, van Binsbergen E, Janecke AR, Bavdekar A, Pandit A, Weirich-Schwaiger H, Witt H, Ellemunter H, Deutsch J, Denk H, Müller W, Sternlieb I, Tanner MS, Wijmenga C. The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. J Hepatol. 2003;38:164-168. PubMed

Bhatia E, Choudhuri G, Sikora SS, Landt O, Kage A, Becker M, Witt H. Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. Gastroenterology. 2002;123:1020-1025. PubMed

Truninger K, Witt H, Köck J, Kage A, Seifert B, Ammann RW, Blum HE, Becker M. Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis. Am J Gastroenterol. 2002;97:1133-1137. PubMed

Witt H. The SPINK in chronic pancreatitis: similar finds, different minds. Gut. 2002;50:590-591. PubMed

Witt H, Kage A, Luck W, Becker M. Alpha1-antitrypsin genotypes in patients with chronic pancreatitis. Scand J Gastroenterol. 2002;37:356-359. PubMed

Witt H, Becker M. Genetics of chronic pancreatitis. J Pediatr Gastroenterol Nutr. 2002;34:125-136. Review. PubMed

Witt H. Gene mutations in children with chronic pancreatitis. Pancreatology. 2001;1:432-438. Review. PubMed

Truninger K, Ammann RW, Blum HE, Witt H. Genetic aspects of chronic pancreatitis: insights into aetiopathogenesis and clinical implications. Swiss Med Wkly. 2001;131:565-574. Review. PubMed

Witt H, Landt O. Rapid detection of the Wilson's disease H1069Q mutation by melting curve analysis with the LightCycler. Clin Chem Lab Med. 2001;39:953-955. PubMed

Witt H, Simon P, Lerch MM. [Genetic aspects of chronic pancreatitis]. Dtsch Med Wochenschr. 2001;126:988-993. Review. PubMed

Witt H, Luck W, Becker M, Böhmig M, Kage A, Truninger K, Ammann RW, O'Reilly D, Kingsnorth A, Schulz HU, Halangk W, Kielstein V, Knoefel WT, Teich N, Keim V. Mutation in the SPINK1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis. JAMA. 2001;285:2716-2717. PubMed

Witt H, Hennies HC, Becker M. SPINK1 mutations in chronic pancreatitis. Gastroenterology. 2001;120:1060-1061. PubMed

Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000;25:213-216. PubMed

Maier RF, Witt H, Bührer C, Mönch E, Köttgen E. HFE gene mutation and transferrin saturation in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 1999;81:F144-145. PubMed

Witt H, Luck W, Becker M. A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology. 1999;117:7-10. PubMed